A GREEN SYNTHESIS OF N-OCTYL CINNAMATE BY SONOCHEMICAL METHOD AND POTENTIAL AS ANTIOXIDANT AND ANTIINFLAMMATORY IN-VITRO
Abstract
Cinnamic acid and its derivatives have a vital role in the synthesis of other important
compounds and as precursors for the synthesis of cinnamic esters. Cinnamic acid and its derivatives
have diverse bioactivity. This compound is able to inhibit the grow process from several species of
bacteria and fungi. In addition, this compound has antioxidant, hepatoprotective, anti-inflammatory,
anxiolytic, insect repellent, antidiabetic and anticholesterolemic activities. One of the cinnamic acid
derivative compounds is n-octyl cinnamate. N-octyl cinnamate is a one of the cinnamic acid
derivative produce from esterifice reaction between cinnamic acid and n-octanol with a concentrated
sulfuric acid catalyst. The sonochemical method is one of the methods develope in this synthesis
process, because it is very easy to do, efficient, with high persen yields, short time and
environmentally friendly. From the results of synthesis, identification of the compound was carried
out by means of melting point and FTIR and NMR spectrophotometry. Based on the interpretation
data from FTIR, 1H-NMR and 13C-NMR show the result of the synthesis is n-octyl cinnamate. The
largest percent yield is produce in 7 hours at temperature 60oC with 7 hours a sonication time. The
activities of antioxidant that show as EC50 value from syntesis n-octyl cinnamate compound was
34.71 g/mL. In anti-inflammatory, n-octyl cinnamate compunds at 100 concentration ppm get %
inhibition of 55.56%.
Keywords:Anti-inflammatory, antioxidant, n-octyl cinnamate, Synthesis, Sonochemistry
