Study of Core Shell n-Octyl Cinnamate in Nano Particle as Anti-Inflamatories

Abstract

N-octyl cinnamic is a compound that has potential as a drug as an antioxidant, antiinflammatory,
but is constrained by the nature of n-octyl cinnamate which is difficult to dissolve in water,
causing low bioavailability in the systemic circulation. To overcome this problem, curcumin is formulated
in the form of nanoparticles using chitosan polymer, a derivative of chitin which can be obtained from crab and shrimp shell waste.

This study aims to synthesize n-octyl cinnamic nanoparticles using a simple coating method using chitosan and sodium alginate and to evaluate the
stability of the nanoparticles in vitro. The characterization of nanoparticles that was carried out
included adsorption efficiency tests, particle size determination using a Particle Size Analyzer and
morphological observations using a Transmission Electron Microscopy (TEM) tool. The antiinflammatory

activity test was carried out to determine the potential of the synthesized compound
using the Bovine Serum Albumin (BSA) method. The results showed that the nanoparticle formula
contained n-octyl cinnamic composition with an adsorption % of 91.02%. The particle size is 68.1 nm
based on particle size analyzer testing with an average size of 519.6 . The morphological observations
showed that the particles were spherical in shape with an uneven surface. The n-octyl
cyanamate/Alginate/Chitosan nanoparticles have anti-inflammatory activity with a % protein
denaturation inhibition of 97.71%. This indicates that n-octyl cyanamate/Alginate/chitosan
nanoparticles have the potential to be developed as an anti-inflammatory drug delivery system.
Keywords:Nanoparticle, Anti-inflammatory, n-octyl cyanamate/Alginate/chitosan, Synthesis.