The Effect of Clinacanthus nutans (Burm.f.) Lindau Water Fraction Addition on Hypoglycemia

Abstract

This research aimed to investigate the effect of administering water
fraction of Clinacanthus nutans [Burm.F.] Lindau (the local name of daun dandang
gendis) in different doses on hypoglycemia. The research method was using the
test of dandang gendis leaves (Clinacanthus nutans (Burm.f.) Lindau) water
fraction on wistar rats using pre and post test method randomized co
ntrol group
design. The induction using a high-fat diet consisting of pork oil: duck egg (3:1)
and fructose 1.8 g/ kgBW for 30 days was applied. Rats were divided into 6
groups: normal control (aquadest), negative control (carboxyl methyl
cellulose/CMC), positive control (metformin), dose
I 15,89 mg/ kgBW (water
fraction of Clinacanthus nutans [Burm.F.] Lindau), dose II 31,78 mg / kgBW, and
dose III 47,67 mg / kgBW. The result showed that a dose of 15,89 mg/ kg BW was
an effective dose to reduce blood glucose level. of wistar male rats induced by
fructose and high-fat feed.

Keywords: Clinacanthus nutans [Burm.F.] Lindau, water fraction, hypoglycemia