OPTIMIZATION FORMULA OF KOLANG-KALING (ARENGA PINNATA.) PEEL-OFF GEL MASK WITH COMBINATION PVA - CMC NA AS GELLING AGENT ON SIMPLEX LATTICE DESIGN

Abstract

Kolang-kaling fruit in topical preparations increase its effectiveness as an antioxidant. The
peel-off gel mask is as an effective topical preparation for skin health and user comfort. Its
formulation is determined by quality parameters, particularly forming a plastic film of
Polyvinyl Alcohol (PVA) and Carboxymethylcellulose Sodium (CMC Na) as polymers. This
study aims to determine the effect of these combination and the ratio of both concentrations
based on the physical characteristics and IC
50
value. The optimization on the simplex lattice
design was obtained in 8 runs with PVA concentrations (10% -15%) and CMC Na (0.5% 5.5%).
The
pH
value,
spreadability,
adhesion,
drying
time,
and
IC50
were
used
as
parameters

to

determine optimal formula. The results showed that the difference in PVA and CMC Na
concentrations had a significant effect on all optimization parameters (p-value <0.05) and the
lack of fit for each replication was not significant (p-value> 0.05). The optimal formula
obtained PVA concentration of 14.97% and CMC Na 0.53% with a predicted pH of 5.55;
adhesion of 6.63 seconds; spread power of 20.34 cm; drying time of 18 minutes, and IC50 of
25.5 ppm (desirability of 0.954), which is not significantly different from the observation
results indicating the optimization is valid.

Keyword: Kolang-kaling, Optimization, Peel-off gel mask, PVA, CMC Na.